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Clb 5,6 (Cdk1)
Clb5 and Clb6 are B-type, S-phase cyclins in yeast that assist in cell cycle regulation.〔Morgan, DO (2007) 'The Cell Cycle: Principles of Control, Oxford University Press〕 Clb5 and Clb6 bind and activate Cdk1, and high levels of these cyclins are required for entering S-phase.〔Schwob, E. and K. Nasmyth (1993). "CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae." Genes & development 7(7a): 1160.〕 S-phase cyclin binding to Cdk1 directly stimulates DNA replication as well as progression to the next phase of the cell cycle.〔Stuart, D. and C. Wittenberg (1998). "CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpoint." Genes & development 12(17): 2698.〕
==Structure==
Clb5 and Clb6 are two of the six B-type cyclins in budding yeast, which contain a short, hydrophobic amino acid sequence that allows targeted degradation and phosphorylation of some proteins that regulate DNA replication. This degradation occurs in late mitosis and is regulated by the anaphase promoting complex (APC).〔 Clb1-6 all target and activate the single yeast cyclin-dependent kinase, Cdk1.〔
Clb6 is encoded by 380 amino acids (44.1kDa), and is 49.7% identical to Clb5.〔 Clb5 is 435 amino acids (50.4 kDa).〔 The hydrophobic box motif is found on the C terminus of both cyclins, and includes the conserved FLRRISK sequence characterizing B-type cyclins.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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